As with all genes we know they are not necessarily your destiny but knowing you have certain gene variants can help you make the best decision with diet and exercise
If I have fat genes am I destined to become fat?
The FTO which is considered the Fat gene is tested in the Health and Well being profile.
Variations in this gene can influence hunger and how the body responds to food.
Hormones Affected by Fat Genes
Key hormones such as leptin,ghrelin and adiponectin are all influenced by the variations in the FTO gene resulting in not only a bigger appetite but also less satiety.
Adiponectin has been associated with blood sugar instability and increased belly fat. Some variants in this gene will increase likelihood of snacking at night and eating an excess of fatty foods.
Fatty foods will then stimulate ghrelin which will further stimulate hunger.
Leptin controls satiety so it makes it hard to control the appetite if you always feel hungry and not completely satisfied
The FTO variants can inhibit the UCP1 gene (also tested in the Health and Wellbeing profile) which can inhibit fat being converted to heat. This results in less fat burning
Protein ,Carbohydrates and Fat Ratios.
Certain variants in the FTO gene require different levels of protein carbohydrate and fat and it is useful knowing this especially if you are having trouble losing weight. While a higher protein diet and lower carb diet can work for many people it’s not ideal for everyone. If protein is too high and you have certain FTO gene variants then inflammation will result which can actually inhibit fat burning.
Genetic Testing for Weight Loss.
Key genes and their variants affecting fat metabolism, energy metabolism and fat burning are tested in the Health and Wellbeing Profile.
- FTO- associated with obesity, weight problems in childhood, over eating, and eating high fat foods.
- ADRB2 and 3-associated with rebound weight gain, decreased tolerance to carbohydrates, difficulty losing weight, increased belly fat, risk of obesity.
- UCP1 and UCP3- associated with decreased ability to convert fat to heat.
- FAB2- decreased glucose tolerance, increased fat absorption, and difficulty losing weight.
- PPARy- poor tolerance to fats, prone to rebound weight gain, difficulty losing weight.
- PPARgCIA-risk of obesity and diabetes due to poor regulation of glucose , fats and energy balance in the body.
- MC4R- risk of obesity and childhood obesity.
- LEPR-1 and 2-regulates appetite and metabolism.
Having specific Fat genes can predispose you to putting on weight however if you know what genes you have then you can use that information to your advantage. It enables you put together a healthy diet and exercise regime targeting those genes and ensuring they express favourably.
The bottom line is: You Can Be Slim and Healthy and Have Fat Genes.