As with all genes, we know they are not necessarily your destiny but knowing you have certain gene variants through a DNA test for weight loss helps you make better decisions about diet and exercise.
If I have fat genes, am I destined to become fat?
The FTO, which is considered the Fat gene, and is tested in the Health and Wellbeing profile.
Variations in this gene can influence hunger and how the body responds to food.
Hormones Affected by Fat Genes
Key hormones such as leptin, ghrelin, and adiponectin are all influenced by the variations in the FTO gene, resulting in a bigger appetite and less satiety.
Adiponectin has been associated with blood sugar instability and increased belly fat. Some variants in this gene will increase the likelihood of snacking at night and eating excess fatty foods.
Fatty foods will then stimulate ghrelin which will further stimulate hunger.
Leptin controls satiety, making it hard to control the appetite if you always feel hungry and not completely satisfied.
The FTO variants can inhibit the UCP1 gene (also tested in the Health and Wellbeing profile), inhibiting fat from being converted to heat. This results in less fat burning.
Protein, Carbohydrates, and Fat Ratios.
Certain variants in the FTO gene require different levels of protein, carbohydrate, and fat. It is useful knowing this, especially if you are having trouble losing weight. While a higher protein diet and lower carb diet can work for many people, it’s not ideal for everyone. If protein is too high and you have certain FTO gene variants, inflammation will result, inhibiting fat burning.
Genetic Testing for Weight Loss.
Key genes and their variants affecting fat metabolism, energy metabolism, and fat burning are tested in the Health and Wellbeing Profile.
- FTO- associated with obesity, weight problems in childhood, overeating, and eating high-fat foods.
- ADRB2 and 3-associated with rebound weight gain, decreased tolerance to carbohydrates, difficulty losing weight, increased belly fat, risk of obesity.
- UCP1 and UCP3- associated with decreased ability to convert fat to heat.
- FAB2- decreased glucose tolerance, increased fat absorption, and difficulty losing weight.
- PPARy- poor tolerance to fats, prone to rebound weight gain, difficulty losing weight.
- PPARgCIA-risk of obesity and diabetes due to poor glucose regulation, fats, and energy balance in the body.
- MC4R- the risk of obesity and childhood obesity.
- LEPR-1 and 2-regulates appetite and metabolism.
Having specific Fat genes can predispose you to weight; however, if you know what genes you have, you can use that information to your advantage. It enables you to put together a healthy diet and exercise regime targeting those genes and ensuring they express favourably.
The bottom line is: You Can Be Slim and Healthy and Have Fat Genes.